Hyperammonemic Encephalopathy due to Valproic Acid and Topiramate Interaction
نویسندگان
چکیده
منابع مشابه
Hyperammonemic Encephalopathy due to Valproic Acid and Topiramate Interaction
Valproic acid-induced hyperammonemic encephalopathy is a rare yet serious adverse drug reaction. Medication interactions such a valproic acid and topiramate can precipitate an event. We present the case of a 52-year-old female that presented with acute mental status change and hypersomnolence due to hyperammonemia caused by a valproic acid derivative. The patient improved after withdrawal of th...
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Valproic acid currently is used as an anticonvulsant medication with a broad spectrum of activity. It usually is used in seizures in children and adults that are not controllable by other anticonvulsants. A documented side effect of valproic acid therapy has been the elevation of the serum ammonia level , with the subsequent development of hyperammonemic encephalopathy. We report the brain magn...
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Encephalopathy resulting from the administration of levetiracetam (LEV) is a rare occurrence. We experienced a patient receiving LEV treated with valproic acid (VPA) for partial seizures with secondary generalization, following which she developed hyperammonemic encephalopathy and showed complete recovery after the drug was withdrawan. LEV is able to promote hyperammonemic encephalopathy when a...
متن کاملA case of hyperammonaemic encephalopathy due to valproic acid.
A patient with valproic acid induced hyperammonaemic encephalopathy is presented. During chronic treatment with valproic acid this patient developed a potentially life-threatening encephalopathy without signs of liver failure. After discontinuing the valproic acid the patient recovered completely. In the case of a patient presenting with hyperammonaemic encephalopathy, the possibility of the us...
متن کاملA Discounted Interaction, Divalproex sodium and Topiramate Induced Hyperammonemic Encephalopathy – A Case Report
An interaction between divalproex sodium and topiramate may induce hyperammonemic encephalopathy, a well-documented, but seemingly overlooked or minimized adverse drug interaction. This case report highlights a 54 year old Caucasian female who presented with sedation, mental status changes, and a history of repeated hospitalizations of similar presentation along with hyperammonemia. The patient...
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ژورنال
عنوان ژورنال: Case Reports in Psychiatry
سال: 2014
ISSN: 2090-682X,2090-6838
DOI: 10.1155/2014/410403